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33-0 Record: Patrick Mahomes Yet to Lose a Single Game to 13 NFL Teams

Patrick Mahomes remains unbeaten against 13 NFL teams: Cardinals (0-2), Falcons (0-2), Panthers (0-2), Bears (0-2), Browns (0-4), Dolphins (0-3), Vikings (0-1), Saints (0-2), Giants (0-2), Jets (0-2), Steelers (0-4), 49ers (0-5), and Commanders (0-2). The Buffalo Bills have beaten Patrick Mahomes the most, with 5 total wins (all in the regular season). Mahomes holds a 5-5 overall record against them.