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What Game Is on Monday Night Football Tonight? (Dec. 22)

MNF this week features the San Francisco 49ers visiting the Indianapolis Colts. Kickoff is set for 8:15 p.m. ET at Lucas Oil Stadium. The game will air live on ESPN, with streaming available on ESPN+ and NFL+. The 49ers enter at 10-4, while the Colts sit at 8-6 with playoff positioning on the line.